Here's a list of who's gone insane or kicked the bucket:
| Character | Player | What Happened | Campaign |
| Nicholas Smuntz | James B. | Turned into a Deep One Hybrid, and later shot to death by Dr. Sotheby during the raid on Innsmouth | Escape From Innsmouth |
| Mike Masrick | Zero J | Retired after losing his mind too many times | Day Of The Beast |
| Dr. Richard Sotheby | Eric F. | Retired | Day Of The Beast |
| Bruce Sotheby | Zero J | Cranium shattered from punch to the head by Baron Hauptmann | Day Of The Beast |
| "Thug" Douglas | James B | Retired after losing a hand when attempting to punch an Avatar of Nyarlathotep | Escape From Innsmouth |